I think there might be a little something funny about suspension geometry on Siennas. My SO has had two - a second gen and now a third gen. On both if you're turning more than, say, crossing over your arms on the wheel you can start to hear a ripping sound from the fronts. If you're getting even close to steering lock, no matter how slow you go it's very noticeable and you can tell the tires are being mangled. If you're pulling a U turn and the outside tire gets into some sand or gravel on the road you can feel that one tire doing a slip/step/pulse sideways every half revolution. Some kind of problem with the Ackermann design or something? Not sure, haven't dug into it, but definitely noticed if you pay attention to noises from Siennas around you.
Also - there's a parking lot with a particular coating that we're at frequently that accentuates squealing. Even in a fairly gradual turn at slow speed it will start squealing away - both the gen2 and gen3. Again, leading back to something scrubbing one tire more than it should be in turns, and getting worse the sharper the turn.
Not an issue found or fixed on standard alignments, witnessed on multiple Siennas, and whatever is behind the obvious bad noises might be behind higher than normal wear, especially with in town suburban driving (lots of turns, accelerating into right turns from stopped etc....). If anyone has specifics I'm curious, not that there can be anything done about it.
I'd have to check with her to be sure. The gen2 had Michelin Defender T+H (I think) on for a period and they were noticeably great - smooth, long lasting, good grip within minivan expectations etc...