It's literally sold as all makes all models safe to mix with anything coolant and comes with a corresponding warranty. Prestone does have actual chemists working on this stuff, and they do research, file lots of patents, and perform all sorts of testing. You will almost certainly get rid of the car long before any differences in coolant performance become apparent. The people concerned with universal coolants containing 2-EHA "eating" stuff somehow never have pictures of anything it's supposedly eaten. The only evidence is GM engine failures from the 90s, where it was a combination of bad design, bad maintenance, and possibly first-gen chemistries, rather than any fundamental issue with the coolant ingredients.
I've run that stuff for 100s of thousands of miles in my vehicles and have never had any cooling problems that could be attributed to a chemical incompatibility. So have hundreds of millions of other people over the last couple of decades that these coolants have been on the market. If there was a major chemical incompatibility issue there, it would have become apparent by now, there would be class action lawsuits, manufacturers would be issuing warnings not to use the stuff, et cetera. None of that is happening.