Yeah, I'd be targeting something that got at least 35 mpg highway with that sort of miles driven per year. I'd rather have the extra ten grand in my pocket, for a year and a half of driving, but that's just me... My vote would be for a gently used Camry or Accord with the 4-cyl (maybe the hybrid, but not necessarily). Drive it to 300k and sleep well, knowing you are saving tons of money. Midsize sedans seem to balance not being a "penalty box" (like some might call, for example, a Yaris/Versa, etc) with being cheap to run... 35-40 mpg hwy, compliant ride, decently feature-rich, plus cheap maintenance and plenty of space. I'd much rather spend that much of my life in something decently comfortable, but there's no sense in doing it in a F350 either. I think a midsize of some nature is a good compromise - you're not going to save too terribly much going from 35-45 mpg (diminishing marginal returns), but there's no way I'd even consider something that didn't get at least 30 mpg. 20 mpg for 216,000 miles is over an fuel tanker of gas in just a year and a half... I'd also second renting before you buy - you need to make sure that you like the seats, driving position, armrests, etc. and other things that may become obvious in mile 200 or 400, but not right away on a test drive.