I've used AdblockPlus for years. Works fine in pretty much every browser. You do have to go into the settings and turn off "show acceptable ads" to block all ads, not just most of them.
Ublock Origin is "better" in theory and some people swear by it, but it's a bit too strict and blocks entire pages or links from email sometimes. A hassle to explain to clients, friends, family, etc. which is why I prefer and recommend ABP.