My parents told me to look both ways before crossing the street, then look again carefully. The very same thing applies here. More than that, it is a written requirement that pilots be familiar with the airport. Modern jets have great moving map airport diagrams too.
The reason I asked the question, is that at some airports it is common to taxi on a runway AND have that runway have normal hold short markings. At other airports those hold short lines are simply not there. There could be a line, or not. The inconsistency is known to ground controllers at airports without hold short lines on runways used as taxiways. They see pilots make this mistake regularly.