IMO, its smart to start moving to syn fluids for the diff in your truck, and that has been known to up your economy a bit.
Is it a manual trans? If so, consider changing that fluid to syn as well. If its an auto, just change the fluid with nissan fluid.
Syn in the engine may help too... but you need to realize the cost penalty you may be taking. If you 'drive so much', then it might very well be worth it to switch to syn oil and extnd your oil change interval out to where youre saving $$$ over normal oil changes.
All of these things are beneficial to reducing lifecycle cost, not just instant fuel economy. You need to realize that the cost of these things may not get paid off for a year or more, in terms of improved fuel economy... if at all. Theyre just smart to do if you want to keep your vehicle.
The best thing you can do is to avoid brisk acceleration and jackrabbit starts at the stoplights, stopsigns, onramps, etc. Youre not a nascar driver, and with fuel as expensive as it is, you cant afford to be one. Accelerate gradually, and try to anticipate stops so you can get your foot off the gas pedal as early as you can to coast. Driving gently is the first key... Once driving, keep it slow... that is the second key to success.
IMO, dont sacrifice your AC life for a bit more fuel economy. Run the AC regularly. Most vehicles see better fuel economy on the highway with windows closed, AC on than ooen windows anyway.
Drive gently!
JMH