A lot of variables, but I'll present a few of examples I witnessed.
- I had a 1999 Lexus GS300. At 365k miles the engine looked like a 50k mile engine under the valve covers. Worked well, until I let a young driver behind the wheel. That driver killed the transmission in 3 weeks. Engine still fine.
- Same driver had a 2003 Lexus IS300. 220k miles. He raced and drifted it at every "takeover" event in town. Engine held up just fine, but it did take 3 transmissions due to such abuse. Then he filled the engine with 0W20 oil... Drove it for couple thousand miles... And decided to do an engine flush by adding 1qt of Motor Medic flush... Needless to say that such a thin mixture provided zero protection to mating surfaces, so Cyl #6 spun a bearing and completely ate up the crank. Engine is currently rebuilt, back in business, and is getting turbocharged by the new owner, also a young guy.
- I had a 220k mile 2001 Honda CR-V 5MT and AWD. Redlined often, lots of offroading, and it all held up well. Until a rear main seal destroyed the clutch. With a new clutch the new owner is still rowing through gears with the sound of B20 screaming for life, but soldiering on somewhere in Kentucky.
With all that and many more other examples - mileage is just a number and precautionary measures need to exist based on intended usage. Planning to stay at higher RPMs often? Up the oil viscosity and go with better oil. Planning to drift or tow with that automatic? Pick a better ATF and install the biggest transmission fluid cooler that can fit in there, as well as get an ATF temp gauge and pay attention to it. Research bigger brake options for the vehicle in question. Stuff like that. Just use common sense and it will be fine.