To answer the OP's question, yes the Honda has iridium plugs and was not spec'ed for them. We have noticed no change in fuel mileage since installation.
It should be said that much was done at the same time, so if there was a change, it would be difficult to attribute anyway.
Although they don't "all spark the same" which you can prove to yourself by watching an oscilloscope, each type of plug will serve fine for the their respective service interval.