You have to replace the "APIM". This is the infotainment "brain" and you can go with a navigation or non-navigation unit. Obviously navigation costs (substantially) more. You want one from a 2017 or newer Ford. You can use APIMs from various other Fords, it doesn't have to be an F-150. You also have to replace the 8" screen with a Sync 3 version. For the screen, you have to get one from a suitable vehicle. Obviously an F-150 will work but other vehicles will to. Ford has "flush" mount screens or "recessed" mount. I don't know what an F-150 uses but it has to match. Lastly, you should replace the USB hub. This is mandatory if you use an Apple device and want to use Apple CarPlay. It's not mandatory if you use Android (and Android Auto) but the system will complain every time saying the hub isn't compatible (it doesn't know nor care at start-up if you're using Apple or Android). Lastly, you have to add a different GPS antenna.
I went non-navigation as we would use Apple Carplay, i.e. Google Maps, Waze, or Apple Maps. Spent $215. I got very lucky with that price. Generally speaking, you're gonna spend $100-150 (APIM), $100 (8" screen), and about $75 in the other misc parts. I bought the APIM and screen from a salvage yard. Got them out of a 2020 Fusion. The other bits I bought new from Amazon, eBay, etc. There may be some "programming" with FORScan required but it's NOT difficult. You can pay some folks to do this too.
You can also buy ready-to-install complete kits with everything but they'll run you $800+.