Ugh that rear most crossmember looks thin.
Get as much of the loose rust off, that will help the lanolin by not having to penetrate as much crud. Dry it really well. then get in to the boxed sections with the spray wand. I suggest a FF or Woolwax sprayer (looks like a paint gun) with wand extensions. Get into the frame, bed crossmembers, rockers and cab corners. Pull the body plugs and spray like a madman. Note that rubber seals and plugs will deform!!! I cover and protect the brake hoses.
Once the inside stuff is done, then brush on the the reachable areas. This is an iterative process. You will find many spots that you miss, so keep doing it over a few months and touch up each year. The big spray gun is good for this.
I've also found that uncovered areas corrode more when the rest of the truck is protected. I've often thought I should use some sacrificial metal, and leave it exposed to protect the remaining parts. Like an anode/cathode of sorts.