In my experience no. All the cars I currently service take 5.5 for the Mazdas or 6.75 for the IS250. Being that I purchase the 5 quart jugs since it is less expensive than individual quart bottles, I often find myself using the full 5 quart jug along with a top off of something else from another 5 quart jug. For example, I just recently changed the oil in my Mazda6, used 5 quart jug of PU 5W-20 and half a quart of QSUD 0W-20. Did the same for the Mazda3 and so far no ill effects. If I have the means, I will purchase two 5 quart jugs, use one for the majority fill and the other jug for the half-quart part etc. until it runs out. In general I'd have no problems mixing oils in the same general [warm] weight [0W-20 to 5W-20 and xW-30s to other xW-30s and so on] from the same parent company in the same general class [syn to syn and conventional to conventional, so PU to QSUD or PP and PYB to QSGB etc.]