There is nothing stopping you from threading metal into plastic with or without using teflon tape. When you use the teflon tape and NPT style fittings they seal with applying pressure to the threads with the tape in-between to take up any remaining gaps and it might cause the plastic you are threading into, to crack under stress if it's not thick in the surrounding areas and not of dense plastic material, or it could cause the plastic threads to buckle under the pressure from the metal fitting if it's too tight because the surface area of the plastic threads are rather thin in NPT fittings. Just some things to think about.
You might be better off using coarser threads when going into plastic.