Only small differences, and greatly depended on vehicle.
'02 accord I4 auto. zero difference, zilch. both engine and trans. BUT, the synth motor oil doesn't "tire" as quickly as dino "tap tap tap"/free-rev smoothness. synth atf is a bit quieter, too. but no discernable mpg difference. 8,500 OCI, at 300 miles/wk.
97 subaru 2.2L MT. all diffs, transmission + engine, a solid 1.5 mpg average increase. Solid 1.5. 450 miles/per week, so I had a lot of data to go by. engine only contriubted 1/3 of that. transmission and rear eng gained the other 2/3. 10,000 OCI.
01 Chrysler T&C 3.3L. engine oil only, mileage fluctuated alot. Achieved as high as 24.5 mpg regularly at 65mph *max* speeds after switching to M1, but also as low as 17 in the same commute. Speed was such a huge factor in mileage that I have to discount any changes. However, the 10,000 OCI on synth was happy, until my commute became shorter. M1 couldn't make it past 6,500 comfortably when I came off the 450 miles/week drive.
'97 pathfinder 3.0L AT 4x4. full synth in engine, maybe too small to notice. full synth in rear diff, Solid .5 mpg increase. full synth in transmission and xfer case, easy 1 mpg increase. Changed to manual lock/unlock front hubs, easy 1 mpg increase. Insulating the stock intake gave another .5 mpg. Went from 18 to 21+ mpg, max speed 65, 10,000 OCI. Note- pathfinder V6 w/ 4 qt sump was hard on oil. The subaru held out to 12.5k when I'd get nervous, 'finder would make a racket under the hood at 11k.
your mileage may vary.
Meep!