ToyotaNSaturn, the "beefier" Enterprise version of Mcafee may indeed be better, but all of my experience with Mcafee has been far from "minimal headaches." A lot of my customers despise how Mcafee operates, as it prompts for everything. Which I believe is good in theory, but a lot of people I help are not big into computers, so they have little to no idea of what is popping up. This is why I agree that Norton is evil, as the newer Norton's (mainly when Internet Security is built in) do the same thing, and block perfectly safe stuff for unknown reasons. Mcafee doesn't seem to be that stable either.
My choices for anti-virus programs are F-secure version 6 (but with Internet Security removed), pre-2004 Norton (as long as the Internet Security is not installed), Trend Micro, or AVG.