I'd so go for it. The LS engines sometimes have accessories that hang lower then the 350 chevrolet ever did, so in some cases you may have to cut into the cross member. It should be a fairly straight forward swap.
Yes, you will need an electric fuel pump, i recommend setting up a return style pump with regulator instead of the return less set up. If your using a factory ECM, you may have to use secondary O2 simulators or install the cats if you have them laying about. I'd try to mount the engine/trans combo as low and far back towards the firewall as reasonably possible for better weight distribution. I'm not sure if you care to have evap, but i recommend keeping the whole system if possible. If not reprogramming the ECM or an aftermarket ECM maybe necessary.