Likewise Sprintman. I had Spybot about 3 minutes on my machine last year and for some reason the tea timer completely hosed my machine and I had to reinstall my operating system (thank goodness for imaging software I have now!!!). It will never see my computer ever again.
97tbird, I really recommend having something running in real time. The only free things I know of that have free real time protection are spyware terminator, and the google pack version of spyware doctor. I have the free spyware doctor and it seems to be working fine; startup is slower but that has been a known fault of spyware doctor for some time. It does scan really really fast with the intelligent scan; like 2 minutes! Excellent IMO.
Spyware terminator is supposed to be pretty decent; not quite the same detection rates as the biggies, but it also has HIPS with it for zero day protection.
There are other free HIPS programs like Dynamic Security Agent and Prevx2, but after using HIPS now for a year, I'm done with it. Every new little thing that legitimately needs to be on your machine, like windows updates, will throw up a bonanza of pop ups similar to a firewall, and twice now, I've had windows updates corruptly install and mess things up because of HIPS.