To check if the misfires are caused by the coils, swap 1 & 2 with 3 & 4. Easy to label them first with a white Sharpie.
Clear the codes, and run the engine again. If the misfire code moves to cylinders 3 & 4, then replace both coils.
Clear the codes, and run the engine again. If the misfire code moves to cylinders 3 & 4, then replace both coils.