KJSmith explained this correctly, above.
But I'll give an actual example such that the clarity of his statement makes sense. Consider the following:
- we are discussing a traditional, 12v, DC, negative ground vehicle (aka "chassis ground" - meaning any conductive part of the chassis is bound to the "-" battery post via one or morel ground straps at various locations
- we are NOT discussing household electrical loads; that's not what the OP was asking about
- you have an electrical load with 15 feet of wiring going from the "+"battery post to the positive side of the load (eg: let's say the "load" is a blower motor for the HVAC)
- that same electrical load has only 2 feet of wiring going to the negative side of the load (because it's a negative ground, it does not need to go all the way back to the battery, it just "grounds" to the firewall or a bulkhead). This is a major cost and weight savings by not having ground wires all run back to the battery; the conductive parts of the chassis are acting as part of the negative wire circuit.
Two conditions could potentially occur to create an electrical problem in regard to vehicle wiring:
1 - breach of the positive side wiring ...
In this example, anywhere along that 15' of "+" wire that would have a bare spot where the positive wire touches any conductive ground spot would cause a short, potentially risking a damaged load device or fire (or parasitic draw for low-load conditions). There exists a myriad of places the wire can be pinched or rub against a sharp spot that would then allow the bare positive wire to "ground out" and cause a problem. In this example, once a positive wire is compromised and connects directly to ground, it no longer needs that 2' of negative wire to complete the circuit. So placing a fuse on the positive side of the circuit stops the flow of electricity if it becomes compromised and blows (melts) the fuse. In fact, the closer you put the fuse to the battery the better, because it protects more of the wiring; if you put the fuse on this side within 2' of the battery, then 13' feet of the remaining "+" wiring are protected, as well as the load itself. Fusing the positive wires as close to the battery as possible protects against the greatest potential for shorts anywhere downstream of the fuse.
2 - breach of the negative side wiring
In this example, none of that 15' of positive wire, nor the load itself, are protected. If you "fuse" the 2' of negative wire, that does not stop an additional short from developing elsewhere along the 15' of positive wire. Fusing the negative side on a negative ground system can stop the flow, but only until a short would develop on the positive side and the circuit would be re-initiated (without any fuse protection).
Hope that helps you understand the "why" a positive side fuse is proper. (The closer to the power source, the better).
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BTW, the concept of breaking the circuit on the supply side of the electricity is the same in household electrical wiring. DC has a positive and negative. But AC has two legs of single phase potential (split by the neutral). Don't think of it as positive or negative; think of it as hot and ground/neutral. With rare exception, you always put the protection device (fuse or breaker) on the supply side ("hot"), as close to the actual supply as possible. In a car, it's in the red wire "hot" side, close to the battery. In a house, it's on the black wire "hot" side in the panel box where the power comes into the structure. This way the supplied power is protected from downstream breach of the wiring.