You have a lot of experience with Auto-Rx; we have developed standard application instructions for all type oils, for people who don't have your knowledge. Complex additive packages contained in synthetic oil and some synthetic blends are rough on seals plus using a synthetic oil to rinse off engine debris is not cost effective.
High mileage blend oils using synthetic esters should follow the Auto-Rx application format for true synthetic oil. If you're going to use high mileage oil with etherified additive to clean for initial application of Auto-Rx, add 2 ounces per quart of oil and drive 1,500 miles. Drop oil and change filter. For rinse cycle use plain non-synthetic oil (Conventional oil) with no Auto-Rx, drive 2,000 miles. Application for engine under 100,000 is done. Look at what has drained out of your engine and also know you have reconditioned seals by the rinse mode.
Engine over 100,000 miles; after driving 2,000 miles as per above instructions, keep non-synthetic oil (Conventional oil) in use, add second bottle of Auto-Rx, drive 750 miles and drain (you have latitude here - you can go to 1,500 miles if you choose as long as filter is able to hold debris). Drain oil and change filter. Now go back to your high mileage oil. Auto-Rx application is finished. No seal leaks.