I'm currently using it, and there have been plenty of others on here that have. I believe it has cleaned up some gunk in the system, because there is a floating layer of brown gunk in my reservoir. That was not there before I put in RMI-25.
It is very very effective! Regardless of the drama in this link I stand by the results. I am one year post RMI25 treatment, and my coolant is bright green for the first time since I've used it. My last drain was 6 months ago, and I feel like I have my cooling system back to new, after it being a slimy mess.