2.7 gave an overall description, and Boomer gave us rigidity—all good.
Frames are like ribs in that they help to maintain shape, in this case, the shape of fuselage barrel. Stringers or Longerons run through or along the frames and are bonded to the frames.
The curved Frames, usually of a U-shape, are formed in a "hydroforming" press for commercial aircraft or, in the case of extremely high stress areas for military aircraft, are forged.
In the Boeing 747 main fuselage of 11 feet in diameter, for example, the Frames are 6.3 inches wide, are spaced every 20 inches, 0.071 inches thick, with the stringers spaced about 8 inches apart.
The skins, or skin panels, are generally attached to the stringers, depending on the design. The skin panels are either riveted or chemically bonded to the stringers, and are generally .063 inches thick.
The skins, frames, and stringers all give rigidity to the fuselage barrel but still allow for some flexing. In certain areas of the fuselage, reinforcing parts called "fail-safe" straps or panels are used to strengthen areas under high stress, such as around window frames.