I think the main argument in the "dino vs. synthetic" debate is cost. Unfortunately.
There is little doubt that synthetics have advantages over mineral oils. These advantages have been stated above (longer OCIs, reduced friction, stand up better to heat, less prone to sludge, cleaner, etc.).
Personally, I can't justify not using synthetic oil. I just spent $22k on a brand new truck and now I'm going to save ~$35 a year by using dino instead? Whether you consider it a waste to spend $5 a quart on oil every 5000 miles is irrelevant. It's a rather small price to pay in the grand scheme of things for a better product.
That's how I've always been with everything. I'd rather spend $5 extra on a shirt at J-Crew that I know will hold up, rather than wasting my money on a shirt at Old Navy, which costs less, but will fall apart after 5 washings.
Just my opinion and obviously I would feel differently if I was driving a beater and spending more money on oil and filters than the car itself was actually worth.