Octane boosters used by the petroleum industry have included tetraethyl lead, MTBE, and ethanol, in roughly that order. (As far as I can determine ethanol was used in corn-belt states instead of MTBE, before the phase-out of MTBE).
I remember seeing commercials that touted "gasohol" back in the 1970s. I think for ADM. And as a kid there were some of those educational short segments on Saturday morning, including one talking about how corn was turned into automotive fuel.
Ethanol as a fuel has been well known for years. The GM engineer who worked on the introduction of tetraethyl lead (and who was hospitalized as a result) actually believed that ethanol would be the better choice. The reason why lead was chosen was complicated, but had to do with it being a gasoline additive as well as the influence of oil companies that worked with GM.
The answer goes back to this day in 1921, when General Motors engineer named Thomas Midgley Jr. told his boss Charles Kettering that he’d discovered a new additive which worked to reduce the “knocking” in car engines. That additive: tetraethyl lead, also called TEL or lead tetraethyl, a highly toxic compound that was discovered in 1854. His discovery continues to have impact that reaches far beyond car owners.
Kettering himself had designed the self-starter a decade before,
wrote James Lincoln Kitman for
The Nation in 2000, and the knocking was a problem he couldn’t wait to solve. It made cars less efficient and more intimidating to consumers because of the loud noise. But there were other effective anti-knock agents. Kitman writes that Midgley himself said he tried any substance he could find in the search for an antiknock, “from melted butter and camphor to ethyl acetate and aluminum chloride.” The most compelling option was actually ethanol.
But from the perspective of GM, Kitman wrote, ethanol wasn’t an option. It couldn’t be patented and GM couldn’t control its production. And oil companies like Du Pont "hated it," he wrote, perceiving it to be a threat to their control of the internal combustion engine.