As to how many drain and fills...lol. That depends on the size of the rad, and how much water actually stays in the block.....I've heard some say garden hose water is just as good as distilled water when it comes to filling the radiator...but me personally, I've always been a distilled kind of guy, I feel with the proper 50/50 and the distilled water, the coolant should at least be able to hold up longer, since it won't have the possible scale/lime/calcium deposits of tap water....I wouldn't worry too much, just keep up on the maintenance, instead of going 5 years on a fluid change, take it to 1-2 years since you didn't use the completely demineralized water...