The question isn't the same as it was 10 or even 5 years ago. Engines are better, and oils are better. While I think it was a no-brainer a few years back to say that synthetics were absolutely the way to go, I'm not convinced there's really much difference now. You'll likely easily reach 250,000 miles on a modern engine with just about any oil you can buy off the shelf. I've always used synthetics. Meanwhile, I've watched my family and friends reach the same upper limits of mileage using brand-name, off-the-shelf dino oil. I just think engines are better made, and the newest oil specs are so much better that the extra protection of a synthetic isn't what it used to be.