Note the Fusion in my sig.. It's at 232,400 miles as of today, and I plan to keep it until at least 350,000, if not longer. My goal is 484,000. I put over 500 miles on it per week, in Phoenix, all year. Even with its advanced mileage, I would have no concerns taking it on a long-distance drive.
Lots on the road, so parts are readily available, proven track record, easy to work on.. and IMHO very reliable. What more could you want?