Home heating oil is just the cheap version of diesel fuel; HHO does not have the added lubricity and detergents necessary for fuel injection systems. Other than that (and no on-road taxes, dye, etc) it's pretty much the same.
Therefore, it's susceptable to the same concerns. Most notably:
1) gel point (aka cloud point, CPP, etc)
2) contamination
As for concern #1, if your tank is stored in an area that gets below 40F, and/or has a line that goes in such an area, you need to use an anti-gel agent. There is a difference between the wax cloud and ice crystals. Depending upon raw fuel used, wax can start to harden as early as 40F, whereas ice crystals can form at 32F. Both need separate treatment plans.
As for concern #2, filtration can help, but also poses issues, because HHO and diesel fuel LOVES to entrain moisture in the fuel. That often encourages folks to use a demulsifier (agent that causes moisture to fall out of suspension). Problem with that is that the water can collect in certain areas, and then micro-organisms can grow; you get bacterial growth that looks very much like "snot" (mucus). This can coat surfaces of filters and clog up lines. So often an anti-microbial agent is also necessary.
If the fuel is not flowing freely, you must ascertain WHY it's not flowing, and discover the root cause, or the wrong treatment might not affect your concern.
I recommend treating the fuel with an anti-microbial at all times; use with every tank fill-up. If you have moisture and/or wax and ice concerns, treat for that too, as needed.