depends on if it has slider cams or rollers, timing chains or belts, wierd hot/cold spots or not, high valve spring pressures or not... (ie a "built" chevy V8 vs a stocker) the former harder than the latter. Then you've got oil cooled turbos (file under "hot spots), high hp per CC displacement per liter of oil capacity (most little Japanese cars)... all tear up oil. More cams means more gears and wear spots on the tips of valves etc.
Old school cars with poor/no PCV venting won't evaporate the crud out of the sump. Imperfect carburetion, overcooling, or mistuned cars can dump fuel past the rings and screw the oil up faster... really anything systematically bad for the engine is bad for the oil.
Getting a bunch of dirt ingested through a bad or poorly designed air filter will screw up the motor and make you want to dump the oil, but that's kind of a chiken-and-egg situation.