I've done a cooler line flush on an 03 Silverado. It's rather straightforward with one exception... dropping the pan is very difficult. There's an exhaust crossover pipe running under the pan. I wasn't in the mood to remove the crossover pipe (not my vehicle), but I was able to undo the pan bolts and slip in a new filter.
Considering this difficulty, I recommend setting aside some extra time to remove the crossover pipe so you can remove the pan for a complete cleaning, replace the filter, and go ahead with the fluid exchange. The first time is most important for cleaning out the break-in debris. Don't bother with the pan for the remaining life of the vehicle, or at least until the next 90K.