For all the commentary on here about how folks are going to maintain their cars to last 300-400k miles, very few do. Very few ever did, and those that did saw mostly highway miles or similar service.
This is because there are many ways a vehicle can degrade and many of those cannot be prevented with "maintenance."
My trusty 2005 Odyssey just took us on a family road trip up to WI. It might be the last such family vacation we take, given one of my kids is in college and the other getting ready for it.
The van rolled 220k miles. Not particularly high mileage, but it's age, not mileage, that can can you. Twenty winters of driving in salt means it has rust. Twenty years of short trips in town (errand running) mean the transmission is near its end (even with regular fluid changes more frequently than Honda recommends).
Honda uses a "subframe" on this generation of vans, and it's isolated from the main body. But what happens when these isolators break down? The ride quality of the van is pretty terrible now, even with fresh new KYBs and soft-riding Nokian tires. It feels "old." There's a clockspring like noise from the steering column every time you turn it. The HVAC makes a chattering sound like it's trying to switch vent modes (or adjust the blend door) but can't.
What amount of "maintenance" will prevent such? None that I can tell. The fact that the engine is in good condition and doesn't seem to consume oil at all is ultimately of no consequence if the vehicle it powers is no longer roadworthy.
By contrast, our GX460-- which is 6 years newer--still rides and drives about like new. This, despite 13 prior winters in Chicago and a lot of undercarriage rust. It's super smooth, has no weird noises or chatters or harshness. This thing lived its first 160k miles in the NW surburbs of chicago driving over potholes and awful pavement. And yet it's as tight as a drum.
The GX will probably be just fine (structurally) until it rusts into dust. The Odyssey will likely never live long enough to rust out as it is just structurally falling apart. It feels like it, anyway.