Maybe WhiteWolf or somebody more knowledgeable than me can chime in here, but it's my understanding that ONE reason GM came out with DexVI was to address shudder problems with some of their newer transmissions... which implies to me that the friction properties of DexVI are at least somewhat different than DexIII.
And even though DexVI has been been declared backwards-compatible... it's still a fact that lots of older transmissions were not designed for this particular fluid. It may be 'close enough', but it simply isn't the same ATF as, say, DexIIIG.
So it should come as no surprise that at some older transmissions don't 'like' DexVI. The 4T65E in my '01 Lumina does NOT work well with DexVI- it made the full-throttle 1-2 shift do a sickening slip & grab thing. I kept the DexVI in there for maybe 25k miles and just avoided full-throttle 1-2 shifts, thinking that maybe the trans. was on its way out. Then just as an experiment, I did a full flush with TranSynd (which claims DexIIIG on the jug- which is what this vehicle originally required). I let the wife drive it for maybe a week before I tried to full-throttle 1-2 shift... to let the clutches soak in the new fluid. And it shifts MUCH better. The full-throttle 1-2 shift is still softer than I'd prefer, but it's perfectly normal. No more slip & grab.
The 4T60E in my '94 Corsica, on the other hand, shifted perfectly with DexVI. Over the years, I ran supertech Dex III, then Penzoil Dex VI, then Transynd in that transmission... and never felt ANY difference in shift quality regardless of what fluid was in there.
So while I don't think there's anything 'wrong' with DexVI, and I would definitely use it in a vehicle that specifies that fluid... it may not be ideal for some older transmissions that were designed for DexIII. And it'll work fine in others... possibly most of them.