High quality synthetic motor oil is generally reputed to keep an engine clean--if it is clean to start with. So I would not think AutoRx maintenance doses are necessary with an ester based synthetic motor oil. But for the initial cleaning AutoRx is supposed to do the job in a couple OCI's whereas the ester based motor oil, may do it, but likely in a lot more OCIs. Nonetheless, I think AutoRx does recommend running a maintenance dose even with synthetic motor oil. But as stated above, you need to run dino during the AutoRx full cleaning process.