Seafoam's primary chemistry is solvent and it can have detrimental effects to seals, etc. if not applied according to instructions; AutoRx is based on esters and bears no detrimental effects to seals (solvent, for what it's worth, is known to attack many elastomeric materials used in cars, such as seals, o-rings, etc.).
Some may claim that Seafoam attacks the dirt/sludge/grime better than the other cleaner but IMHO I like it the gentle way, non-invasive way such as AutoRx.