As with most things regarding oil, there is no hard and fast rule. With some engines, the answer to your question is "yes"; with others, "no." My Saturn has had synthetic it's entire 214,000-mile life, yes, changed on average every 4,000 miles. Always Mobil 1, with short adventures with Redline or Amsoil. Engine still got dirty. Really dirty. Rings froze in their grooves, etc. The oil turns jet-black in a matter of 1000 miles. Always been that way, since day 1. You're looking for a rule of thumb: there isn't any. Those who say things like, "If you use Oil Brand X, you shouldn't ever have to clean your engine" are basing that conclusion on their subjective experience. My subjective experience says that's silly. Why? Because I drive a Saturn! Bottom line, you have no way of knowing without trying it for a few tens of thousands of miles, and then pulling things apart to see for yourself.