After using FF for years, I made the switch to Google Chrome after experiencing all of the issues that began to manifest somewhere around version 3.10 and haven't looked back. There was a slight learning curve associated with using Chrome, and I felt out of my comfort zone, but this only lasted for a few days.
I use Ad Muncher to stop pop-ups and advertisements. Ad Muncher costs about $23 USD and in my opinion it blows away AdBlock Plus. Google Chrome and Ad Muncher (Beta version 4.73) run flawlessly on my desktop computer using the RTM build of Windows7 Professional.
Making the switch to Chrome was easy once I realized that I didn't need all of the add-ons that I used with FF. Chrome strives to be what FF once was, a lean, fast, secure, standards compliant web browswer.