Depends upon car, usage, and maintenance, which is obvious. Our 89 Civic only lasted 125k miles before we donated it as it was low on compression in a cyclinder, blowing blue smoke, etc., evidently because the little 1.5L engine couldn't handle driving our family up and down the hill that we live on. My son's 92 F150 with a 4.9L I6 with 140k mils on it barely uses any oil, just passed smog with excellent results, but it's needed universal joints, ball joints, starter, alternator, and such. I have a Dodge with a Cummins and expect at least 500k miles. Police departments seem to acknowledge that RWD vehicles are more durable than FWD, which is different than overall reliability.