They do pull more solidly that a bumper hitch. You're going to take an MPG hit for the weight and taller trailer. My BIL tows a similar size with his 6.6 gas 2500 Silverado and gets 8 mpg
at best, IDK how fast he tows. My bumper pull trailer is similar to yours and over 30k miles of towing @65 in the West with a 6.6 gas Sierra I'm right at 10 mpg.
You'll have to re-learn backing up and turning in, it's a bit different with a 5th wheel. You have to pay attention to overhead when getting gas, newer stations seem to be really high, older ones not so much. Depending on your truck and how much bed rail to trailer clearance you have you really have to watch sharp dips or rises or diagonal twists like going through a drainage channel or ditch. Let someone out to spot you so you don't crunch your bed rails.
My daughter-in-law had the same Andersen hitch with a fairly large toyhauler and the 4 allen head bolts that tighten the kingpin block kept coming loose, not sure if it was user error or what but something to keep an eye on.
Andersen Hitch video
The good thing about Andersen hitches is the light weight. The question mark is all aluminum construction including the ball. The accident linked to is a bit suspect, like maybe the ball broke
after he hit the vehicle ahead?
Safe travels and good times with your new trailer.