My anecdotes: Every time I've switched to synthetic on a car that did not leak or only leaked a little, the leaks/consumption began or increased, and when I went back to synblend or conventional, the situation improved.
I tried Mobil 1 in my '86 MB 420SEL. Leaked. Leaks vanished when I went back to Valvoline conventional.
Tried Castrol Edge in my '03 Buick with the 3.8. Leaks increased a lot, and decreased to the previous level after I changed back to conventional.
Tried Quaker State Ultimate Durability in my 2.4-engined '11 Regal. Lost 2 quarts in 1500 miles. Have gone back to the AC Delco cynblend, and after 3000 miles there has been no oil lost.
Only the MB was over 100K miles; the others were well under that mark. I dunno, but I think I'm going to skip synthetic until I buy my next new car, which isn't very likely.
Mine is only 1 case (or 3), though, and the vast majority of posters here have had no trouble switching.