MaxSecure is pretty good. It's what I currently run on my PC. SpySweeper is downright obnoxious. It's not a "set and forget" product-it's constantly jumping up in your face. And with the fiasco of their most current enterprise version I have trouble supporting them in any way.
Unlike antivirus software, you can run multiple antispyware software products on your PC. However you should be fine IF you have a basic antispyware software program and use some common sense on the Internet.
While the statement "No one program does them all. Same goes for Anti-virus." is true for antispyware products, there are several antivirus programs with a 99.5+% detection rate (per av-comparatives site) My personal choice, Kaspersky, has a 99.9% rate (total without DOS or other OS viruses). Besides, you should never run multiple antivirus products on one PC at the same time. It's asking for trouble.