Still leaves more questions than answers for me. Silica/silicate technology has been outdated since the introduction of aluminum/cast iron mixed blocks as well as all aluminum blocks and heads,, hence the introduction of Dexcool by GM. My 1999 STS had Dexcool from the factory.
Anyway, I'd really like to know, as would the original poster, whether the coolant needs to be changed on a 2018 and newer E class vehicle. Reports of additive "bars" dissolving in expansion tanks using the current coolant chemistry, and the fact that nowhere in the service manual is a coolant change required, only adds to the mystery.
I'd really like to know the truth, but Mercedes would much rather get you in for service than share that info.