My 98 chevy truck cools like day 1, never been touched.
Unless you really control your lines, every time you fill up, youll also introduce a bit of air and humidity.
There is a dryer to scavenge it, but the fewer times you have to open the system, the better.
There is no reason to have to add refrigerant at 50k. I have original systems that are 20+ years old and 220K+ miles on them... And window AC units that are 20 years old and still cool like champs...
There can be leakage, especially if the system isnt used regularly, as seals can dry out and then be more leak prone. We run our AC systems year round, nearly 100% of the time, and still beat EPA highway mileage, so if you drive right, it isnt that huge an efficiency killer.
Top it up if you sense it isnt cooling as good as normal. You can look at equilibrium pressure of a cold-soaked AC system (pressure vs. abmient temp charts exist) to ensure that your fill is nearly 100% correct. That might give you peace of mind.
But Id rather avoid opening or tapping the system unless I had need to do so.
JMH