We have a 2013 Camry SE.
The SE does have a harder ride than the LE.
It is a good highway cruiser - comfortable and competent.
Noise, cabin space and rear seat are very good for the price.
I would never choose a Pruis, Yaris, or Fit over a Camry for highway trips. Those cars are so much noisier, and less powerful
On a few long trips I have hit a solid 40 MPG, but these were ideal conditions:
75 MPH, summer gasoline, cool temperatures so AC was not needed.
On a 95 degree summer day that drops to 37 MPG:
75 MPH, summer gasoline, hot air and blazing sun, heavy AC usage.
In the winter the MPG drops dramatically to 33 MPG:
75 MPH, winter gasoline, no AC.
Add rain or other weather complications to that winter day and it drops another 1 or 2 MPG.
From those experiences I'd say that the biggest MPG offender is the winter gasoline formulation.
Transmission service is a PITA.