I posted this in another thread so I hope it is not considered improper to repost it here...
Here in Atlanta, word on the street is "fear the OEM synthetic gear lubes". Several rearend shops report much higher failure rates with synthetic dope than conventional. Many refuse to use any brand of synthetic to avoid the extra risk of falure.
My source on this is a guy who has been doing gear sets and total rebuilds of RWD axles for many years. He does 200-300 of them a year. From 50's Chevys, including early Vette rears to monster 4x4's to classic musclecar 12 bolt conversions and even regular late model trucks, suv's and vans.
His personal failure rate is 3 rearends gone bad out of over 1,000 that he has at least put a new crush sleeve in, where most are either gear replacements and/or new bearings. He's good and many gear changes he has success with are used gear swaps from a different rearend. You have to be good to have zero failures from using used gears you know.
While no explaination exists for why there are so many failures associated with synthetic gear lubes, whether real or not, there is apparantly enough rumors going around where many who rebuild rearends for a living, at least in this area, are refusing to use any sythetic.
My friend recommends 20k changes of the dope with convetional fluids for 3.55 ratio's or higher. He likes Valvoline but is fine with any major brand. But for lower gears like 4.10, he recommends more frequent changes if you ant to see 300,000 miles of service.