I'm a Lean Mass Hyper-Responder (LMHR) Now - You?

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Here's the ABSTRACT of the Keto CTA study​

Background
Carbohydrate-restricted diets are gaining popularity, including among lean individuals. In these populations, a lipid phenotype often emerges comprising elevated LDL cholesterol (LDL-C), alongside elevated HDL-C and low triglycerides, termed the lean mass hyper-responder (LMHR).
Objective
To evaluate one-year coronary plaque progression in LMHRs and near-LMHRs.
Methods
This prospective study followed 100 participants who developed the triad of high LDL-C, high HDL-C, and low triglycerides after adopting a ketogenic diet over one year. Coronary plaque changes were assessed using coronary CT angiography and analyzed using the prespecified QAngio® methodology (Leiden, the Netherlands), with AI-enabled coronary plaque analysis (AI-CPA; HeartFlow® Inc., Mountain View, CA) used as an independent, blinded confirmatory analysis. Plaque burden and plaque progression predictors were examined using linear regression.
Results
All 100 participants with elevated LDL-C and a mean BMI of 22.5 ± 2.7 kg/m2 completed the study. At baseline, 57 (57%) had zero CAC. After follow-up, most participants remained with low-risk plaque burden markers: 81% of participants had a CAC score <100, and 54% had a CAC of 0. The median increase in non-calcified plaque volume was 5.6 mm³ (37% relative increase). Notably, 15% of participants exhibited plaque regression despite sustaining elevated LDL-C (mean 242 mg/dL) and ApoB (mean 180 mg/dL). Additionally, 78% had percent atheroma volume (PAV) below the high-risk threshold of 2.6%, and 93% had total plaque volume (TPV) below the high-risk threshold of 254 mm³. Baseline plaque metrics were consistently predictive of plaque progression. By contrast, neither ApoB levels nor cumulative LDL-C exposure predicted plaque progression in this population of LMHR and near-LMHR individuals.
Conclusion
These findings suggest that over one year, progression was modest and heterogeneous in this population, with baseline coronary plaque emerging as the strongest predictor of subsequent plaque progression in LMHRs Plaque Begets Plaque, whereas traditional lipid markers such as ApoB and LDL are not
 
@jetman , since you're into heart rate and exercise zones have you considered doing max HR runs then you'll know exactly what it is and can set your zones precisely? When I was racing and taking training seriously and wearing an HR monitor (BITD) I'd do a MHR session every couple of months to see how my high intensity training was going. I hated doing it but it was necessary.
 
AZjeff said:
@jetman , since you're into heart rate and exercise zones have you considered doing max HR runs then you'll know exactly what it is and can set your zones precisely? When I was racing and taking training seriously and wearing an HR monitor (BITD) I'd do a MHR session every couple of months to see how my high intensity training was going. I hated doing it but it was necessary.
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Yes, see post#66 above.
you can see what is what in the garmin connect data I provided.
I did 2 high intensity interval attacks on the steep climb on the way back to find my max.
I'm 68 yrs old now.
I'm an x-racer (running, triathlons, cycling). These days I'm exercising only for health & fitness. Last race I did was almost 13 yrs ago (Leadville SilverRush 50MTB-6+ hrs)
 
jetman said:
Yes, see post#66 above.
you can see what is what in the garmin connect data I provided.
I did 2 high intensity interval attacks on the steep climb on the way back to find my max.
I'm 68 yrs old now.
I'm an x-racer (running, triathlons, cycling). These days I'm exercising only for health & fitness. Last race I did was almost 13 yrs ago (Leadville SilverRush 50MTB-6+ hrs)
Click to expand...
@AZjeff
I got a Garmin 305 again and recorded the data on my ride just for curiosity sake. I do this ride daily and have been doing it since May 2025 in the warmer months. I do a longer 3+ hr ride occasionally that I'll record once too. I can compare my current data to my ole 2010-2016 data on the same courses and see what is what :)
The only time I'll wear the 305 is when I need some new to me course data.
 
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alarmguy said:
Yeah, sometimes you cant get past genetics. Sadly, wow that is some family history.
As far as when someone like your mother in law at 98. I have a mother in law at 94 and still to this day, is 100% there, always on her iPad and FaceTiming etc. All she takes is a statin and I THINK mild BP pill.

Anyway, up until the last 40ish years, the food we ate (and they ate) in the USA was mostly wholesome less processed including the animal protein, way more so for the first 50 years of their lives. Yes, genetics pay a roll but my Mother in law from another country is in great health, more of a 3rd world country but they are considered affluent as well as all the family members, heck live better than here in the USA. Yet here in the USA who two of her daughters came to live in their very early 20s at the time, so spent 35 to 40 years here in the USA both had to be treated for breast cancer. SO figure, yes genetics but I am a firm believer that the food we eat puts us at a disadvantage for sure.
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I agree with you on the food. What we eat today is nothing compared to even 50 years ago and it shows in our health. My neighbors still have kids living at home and I've tried my best to get them interested in gardening but they think food from the dirt is awful and too much work.
 
@jetman I'm the same age as you for a few more weeks and ride mountain bikes 3-4x/week for fun and fitness. Suffering like a rented mule doing 3 hour + rides or high intensity intervals just because isn't in my fun category any more. I see HR in the 150s at the top of some hard climbs but it's because I refuse to get off and push. Maybe I'll do a set of MHR intervals. Or not. It's fun to be old and fit.
 
Arc said:
... @ 61 I'm the oldest living man on my entire side of the family and sure enough I got Cll leukemia at 50 just like my late grandmother. So much for all those years of exercise and eating right.
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BTW- I read over my last response and I wanted to wish you continued hope and success with leukemia.
Cancer sucks. I went through radiation and drug therapy for prostate cancer last year. I understand you would trade places with me in a heart beat over your cancer.
Still, it sucks, the media made prostate cancer sound like it's not a big deal. Well it is, even if successful treatment, you for the rest of your life will wonder every blood test if it comes back. If it gets to the bones, it's a life long suppression drug if you are lucky, the alternative isnt good, seems like as you get older the numbers grow of people I know who died from it or are in not a great place.

Collateral damage from radiation or removal will most likely affect the rest of your life. It is a very treatable cancer but the ignorance of the media (that is changing) makes it sound like it's not a big deal. Ask anyone who has/had it and they will tell you different. My docotor tells me I have a 90% change of living another 15 years.

Ok, once again Im off the subject. I just wanted to wish you the best. I wouldnt want to trade places with you from what I understand.

As far as genes I have another strong strike against me, however I learned at an early age to mitigate it.
Heart disease. The male side of my family is a train wreck with diabetes and quad heart by pass surgeries, internal AED devices etc.
Ive been VERY proactive never wanting to go through it but I do have those bad genes. However walking a tightrope I dont have Type 2 yet nor have I needed heart intervention. However I do have heart disease and many, many tests and also an invasive angiogram. So far I am at only around 20 ish percent of plaque all over the place which is excellent. But I have that gene. High Lipo A and a CAC score of 477 still manageable but a tight rope.

Anyway, once again, truly, wish you the best in your fight.
 
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There has been a video posted at least two times in this thread pointing out the shortcomings of this Keto CTA Study.
Im completely neutral however I like factual data and I am not convinced nor are the respected by people in here, doctors in those videos. (Post #70)
Here is further damaging thoughts and opinions by other people studying the report (besides the respected ones in Post #70)
Studies take years and years, one year and 100 carefully vetted healthy people in what is called a flawed study if you want to apply it to the general population. We are all different, this is certainly not one size fits all.

"One way to gauge the magnitude of these findings is to compare against plaque progression rates reported in other studies (especially since this trial lacked its own control group). The numbers paint a stark picture: LMHRs had plaque growth equal to or exceeding that of much “higher-risk” populations."
https://drstanfield.com/blogs/articles/lean-mass-hyper-responders-see-rapid-plaque-progression
 
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jetman said:
Today I did the same ride as yesterday at the same avg speed/elapsed time. Today my avg HR was 150, 11 bpm higher than yesterday, and max HR was 173, 9 bpm higher than yesterday.

I guess the difference was caused because: a) It was 20 degrees warmer today and b) I rode after I ate today. Yesterday I rode before I ate.

I will raise my max HR in the Garmin to 173. Of course all my zone #s will increase a bit.

Here's the garmin connect data from today: https://connect.garmin.com/app/activity/22354801370
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What is speed/time difference between riding my 31 Lb fat low pressure tire full suspension mtn bike
and
riding my 16 Lb skinny high pressure tire road bike
on the same hilly road course?

Mtn bike = 59 mins, avg HR 150 bpm, avg speed 11.6 mph
Road bike = 47 mins, avg HR 147, avg speed 14.3 mph
Big difference :)

but ride quality sucks on the road bike :( about shook the fillings out of my teeth.
I'm stickin to my smooth riding mtn bike for road exercise rides.
 
My son left his old mountain bike here when he moved out so I'm going to steal the spring loaded seat post shock absorber thingy from it and put it on mine. :)
 
alarmguy said:
There has been a video posted at least two times in this thread pointing out the shortcomings of this Keto CTA Study.
Im completely neutral however I like factual data and I am not convinced nor are the respected by people in here, doctors in those videos. (Post #70)
Here is further damaging thoughts and opinions by other people studying the report (besides the respected ones in Post #70)
Studies take years and years, one year and 100 carefully vetted healthy people in what is called a flawed study if you want to apply it to the general population. We are all different, this is certainly not one size fits all.

"One way to gauge the magnitude of these findings is to compare against plaque progression rates reported in other studies (especially since this trial lacked its own control group). The numbers paint a stark picture: LMHRs had plaque growth equal to or exceeding that of much “higher-risk” populations."
https://drstanfield.com/blogs/articles/lean-mass-hyper-responders-see-rapid-plaque-progression
Click to expand...
I see/understand/comprehend these things much differently than @alarmguy almost 100% of the time.

BTW @alarmguy , there was a control group = "Miami Heart". You would know this if you had actually read/watched/understood/comprehended the various post made on the subject.

Excuses?
 
jetman said:
I see/understand/comprehend these things much differently than @alarmguy almost 100% of the time.

BTW @alarmguy , there was a control group = "Miami Heart". You would know this if you had actually read/watched/understood/comprehended the various post made on the subject.

Excuses?
Click to expand...
Excuses for what?

This is the most freaking bizarre post I ever saw from you. Like wow out there like some of your other posts, but this one takes the cake.

Your comprehension seems to go with the sources of information you want to believe in, even when they’re discredited and the positive comments withdrawn by the respected people/doctors mentioned many times in these threads. You still seem to have trouble comprehending that and continue the narrative using the same discredited study.

Did you comprehend and have any comments on the link in post number 90?
Any “ excuses” for no response on that?
Your post to me is so far out there I’m not sure you even understand what you’re posting about.
You can’t be disagreeing with me because I didn’t post anything except the link, a source of information, from a doctor, who studied the results of these tests that you so often referred to.

I posted a source of information not an opinion piece.

If nothing constructive don’t bother replying.
 
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jetman said:
16 Lb skinny high pressure tire road bike
Click to expand...

Please describe 16 lb road bike!

ripcord said:
My son left his old mountain bike here when he moved out so I'm going to steal the spring loaded seat post shock absorber thingy from it and put it on mine. :)
Click to expand...

Maybe. The post has to be the same diameter. You can fool around with shims if the post is smaller but they usually don't work well. There are lots of different diameters.
 
AZjeff said:
Please describe 16 lb road bike!
Click to expand...
15 yr old Ebay china carbon frame, wheels, 10 speed SRAM Rival group. <$1000 into it.
DSCN9514.webp
 
Japan has been dismantling the cholesterol hypothesis every passing decade on steak at a time :)
More meat, less fish, higher cholesterol, living longer, growing taller, those darn Japanese.
The Japanese Diet Paradox: What It Tells Us About Cholesterol and Longevity
 
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