Our previous residences in NW & NE Ohio we had thermostats programmed around our work schedules but left pretty much constant on our days off. The programming cycled most in the coldest 6 months in the year, the warmest 6 months of the year were left near constant set point.
Now that I'm retired, and have been basically confined to quarters for health issues much of the time since we moved back to Texas, the thermostats only get adjusted seasonally and when my wife's elderly parents visit. Our Texas and Louisiana houses have been all electric, so the real impact is thermostat setting during the warmest 6 months of the year. We don't futz with thermostat set points during that cycle because trying to play catch-up with A/C is a good way to have the system freeze up and then you swelter waiting for it to thaw out. Better to just let it steadily do its job.