Being that you drive a sienna, you are probably interested in quietness, good balance between dry and rain traction, and longevity. Bridgestone Serenity if they come in your size is an /excellent/ all around tire; we have them on two vehicles now. They are directional, however, which some people do not prefer. A non-direction, excellent tire by bridgestone is the Dueler- is also a very good tire in all regards (neither of these are bad in snow, but they are NOT snow tires). Cooper CS5 as listed above would also be a great tire, though I can't attest to treadwear. We put CS3s on my step-daughter's car and they have been very good.