I cannot confirm the original source of the following, but it seems to address the question at had.
Found at:
http://www.mx6.com/forums/showthread.php?t=94615
Poster:
lordy611
"My name is Rich Eklund, I work as chemical formulation consultant to the Auto-Rx Group. Your question is loud and clear. The web site people will be correcting the confusion. I am pleased to see that ARX has some astute readers.
To answer your question, "Will ARX work with Synthetics?", the answer is yes. May I qualify that this is true whereby your goal is to clean out deposits and contaminants in a relatively well maintained machine. In other words a preventative maintenance application. Auto-Rx and its combination of cleaning esters will certainly enhance a full synthetic's ability to clean while performing its primary objective of lubricating. Most oils have only the amount of detergency to maintain a clean system, not clean a dirty one. So what happens is that if you put clean oil in a dirty motor, the detergent package gets consumed long before the scheduled oil drain and what initial cleaning occurred with fresh change, you give back at the end, and may be more over time. ARX will give the host oil many times over , the cleaning capacity of the host oil. The oil is still capable of lubricating, while the ARX slowly clean the deposits.
However, if you attempting to address a rotational seal issue, such as front or rear main seal or cam seal, then I would suggest using a dino oil and follow the instruction on the ART site.
If you have a very high mileage dirty motor, that will need two or more applications, I would suggest dino again for the sheer cost of running back to back cleanings.
ARX cleans a bit faster when run with dino oil. Reason being, ARX composed entirely of esters are polar and have somewhat of an attraction to metal. With dino's there are no other large quantities of polar materials and ARX has little competetion for the metal surfaces. In full synthetics, typically you a PAO lubricating base, combined with esters to hold the oils additive package in suspension. These coupling esters will compete with ARX for space on the metal surfaces. May I also note that many group III dino derived/refined base oils are marketed as full synthetic. ARX will work great with these as well.
So in conclusion, yes you may run ARX with a full synthetic and enjoy good results. However if you have rotational seal issues, dino would be your choice.
Hope this is helpful to you. Any further questions, write us back.
Best Regards,
Rich Eklund"