Actually JJ, I think just the opposite. The cleaning action that most synth's have are normally exceptional and I can understand completly why auto rx went with esters due to this. The problem I noticed is that if someone with any amount of miles on an engine, haveing used a conventional ok motor oil that doesn't have this type of cleaning action, that has incurred some buildup on the seals, goes to a synth and that starts to clean the seals and such. In many cases, I have seen and heard many state that after I switched to a synth my engine developed all sorts of leaks. I can see why. Because if you have slightly harden seals, and a full synth comes along and cleans off the crud that is on there and currently is helping seal the worn seal, then it can very easily create a leak. This is not to say the synth is bad for the seals. Just that this is would be one reason not to just switch to a full synth in this kind of case without doing a purge with 131 neutra or auto rx as both will do the cleaning and condition the seals back to where they can handle the synth oil.
IMO, a basic synth oil doesn't actually condition the seals, but just like you stated, if it can keep them clean, and keep oil on them with no crud build up, then the seals would / should have no problems lasting.