The C-5 is a remarkable aircraft, particularly when you consider that it is a 45 year old design.
It requires a great deal more maintenance than would be practical in commercial operations, and has required some structural mods. It was not designed or built to have the fatigue life of a commercial transport.
OTOH, a C-5 can land on unimproved runways and sits low enough on its gear that it can be unloaded using its front and rear ramps with no ground equipment, something no large commercial aircraft can do, although both the B727-100 and B737-200 could be equiped to operate from gravel runways.
In terms of weight, The B747-400, a development of a design of a vintage similar to the C-5, can operate at up to 910,000 pounds, although only from paved runways, of course.
The MD-11 can weigh up to 630,000 pounds for take off.