I've read that for an ester to break down into an acid and alcohol takes extreme heat and high humidity. Inside an engine this probably isn't usually the case (my guess). Different esters have different levels of hydrolytic stability as well, and I'm sure good companies are on top of that. An example of a super long drain, primarily ester oil is Motul E-Tech 0W-40; it meets VW 503.01 spec and has proven it can go the distance (~16k miles) in UOAs too (TBN-wise).